Cooperative Research Units
Education, Research And Technical Assistance For Managing Our Natural Resources
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Multigenerational, Multi Species Test for Endocrine Disrupting Chemical Effects

Duration

April 2009 - January 2012

Narrative

Determine precision and accuracy of US EPA proposed avian 2-generation test protocol for evaluating EDC adverse effects on wildlife populations.
� Evaluate relevant endpoints and biomarkers that may increase the sensitivity of the risk analyses and increase the knowledge base of EDC effects on the JQ model.
� Determine sensitivity of the response of the JQ model relative to that measured in alternative wildlife vertebrate species.

Specific hypotheses to be tested for Objective 1 (present task) include:

1, Exposure to EDC after hatch and prior to sex maturation does not affect fertility and productivity.
F0 treated = F0 control for growth measures and food consumption; onset of secondary sex characteristics; onset of mating behavior; # of eggs laid, % fertile eggs; eggshell quality; circulating hormones; gonadal development; hormonal profiles during sexual maturation; embryonic % female.

2. Continuous exposure of offspring to EDC from day 1 of development through pair formation does not affect fertilization; organizational and activational development.
F1 treated = F1 control for: embryonic survival of males and females; embryonic development and hatchability; gonadal development; hormonal profiles in FI during critical development stages; onset of secondary sex characteristics; growth; onset of mating behavior; F1 fertility and productivity.

3. Exposure to EDC in ovo during embryonic development does not affect organizational and activational development.
F2 treated = F2 control for: % female; embryonic survival of males and females; gonadal development; hormonal profiles in F2 during critical development stages; onset of secondary sex characteristics; growth; onset of mating behavior.

 

Current Staff

Federal Staff: 102

Masters Students: 247

Phd Students: 163

Post Docs: 55

University Staff: 266

5 Year Summary

Students graduated: 722

Scientific Publications: 1960

Presentations: 4355

 

Personnel

  • Michael VaughanPrincipal Investigator

Funding Agencies

  • Patuxent Wildlife Research Center

Cooperative Research Units Program Headquarters Cooperators