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Reproductive Consequences of Exposure to Exogenous Estrogens

Duration

July 2005 - June 2008

Narrative

Endocrine disrupting chemicals (EDCs) have been detected in surface waters worldwide and can lead to developmental and reproductive disruption in exposed fishes. In the Great Plains, EDCs are impacting streams and rivers and may be causing adverse reproductive effects. To examine how estrogenic EDCs might affect reproductive success of plains fishes, we experimentally exposed male red shiners (Cyprinella lutrensis) to exogenous 17β-estradiol. We characterized the effects of estradiol on male gonadal histology and secondary sexual characteristics, determined whether exposure reduced reproductive success, and examined the effects of depuration. Adults were exposed to a mean concentration of 70 ngL-1 estradiol, a solvent control, or a water control for at least 83 d. Male exposure to estradiol resulted in elevated plasma vitellogenin concentrations, changes in spermatogenesis, reduced mating coloration and tubercles, altered mating behaviors, and reduced reproductive success with no viable progeny produced. Reproductive endpoints improved upon depuration (28 d). Exposure to estradiol had significant adverse effects on red shiners, indicating that wild populations may face developmental and reproductive difficulties if they are chronically exposed to estradiol.

Research Products and Activities

Peer Reviewed Publications

  • McGree, M.M., D.L. Winkelman, N.K. Vieira, and A. Vajda. 2009. Reproductive failure of the red shiner after acute exposure to an exogenous estrogen. Canadian Journal of Fisheries and Aquatic Sciences 67:1730-1743. Download  |  Publisher Website | 

Thesis

  • McGree, M. 2008. Exposure to 17beta-estradiol alters reproduction of the adult red shiner (cyprinella lutrensis). Department of Fish, Wildlife, and Conservation Biology, Master of Science, Colorado State University, Fort Collins, ColoradoDownload  | 
 

Current Staff

Federal Staff: 102

Masters Students: 247

Phd Students: 163

Post Docs: 55

University Staff: 266

5 Year Summary

Students graduated: 722

Scientific Publications: 1960

Presentations: 4355

 

Personnel

Funding Agencies

  • Colorado Division of Wildlife

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